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KMID : 0605620090160030149
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Journal of Korean Society of Biological Psychiatry
2009 Volume.16 No. 3 p.149 ~ p.158
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Association Analysis of Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene with Schizophrenia in the Korean Population
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Moon Hyun-Il
Lee Yeon-Jung
Park Byung-Rae
Shin Hyoung-Doo
Choi Ihn-Geun
Han Sun-Ho
Woo Sung-Il
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Abstract
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Objectives：This study was designed to investigate the association of schizophrenia and P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene in Korean patients.
Methods： We analyzed P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene from their DNAs extracted from their blood in 388 Korean schizophrenic patients (male 198, female 190) and 372 control subjects(male 247, female 125). We compared the differences of genotype and allele distributions of the six polymorphisms on DTNBP1 gene between the Korean schizophrenic patient group and the normal control group.
Results：There were no statistically significant differences of genotype and allele distributions of the P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene between the schizophrenic patient group and the normal control group.
Conclusion：The results of this study suggest that P1320, P1325, P1635, P1655, P1763 and SNP A polymorphism on DTNBP1 gene do not have influence on the risk of the schizophnenic in the Korean population.
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KEYWORD
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Dystrobrevin Binding Protein 1(DTNBP1), Schizophrenia, Genetic polymorphism
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